Medical Science 21

How to Think About “Risk” Part 2

December 13, 2023


People fear risk much more when an outcome is not in their control.

 Nano-rare diseases strip power from families and this often leads to hopelessness, anger, and dread. However, channeling these intense emotions to carefully navigate risk/benefit decisions is within one’s control.

n-Lorem is different than standard drug development settings. Every risk/benefit decision that n-Lorem makes is in the context of the individual patient’s symptoms, status, and needs. While we cannot promise benefit, we can promise that we will do our very best in the creation of an optimal medicine.

On This Episode We Discuss:

  • Risk/benefit decisions
  • n-Lorem is different
  • We cannot make promises
  • Communicating about risk
  • Perceptions concerning control
  • Exposure and risk
  • Compression
  • Omission
  • Timing
  • Official positions affect our perceptions
  • Anchoring and communicating risk

Watch on YouTube:

Download Script:

For more information on the covered topics or to follow along with this Intro to Medical Science episode, download the supporting transcript.



For definitions of terms, search our glossary.


The host of the show is Dr. Stanley Crooke, a scientist, a physician, an entrepreneur and the father of antisense technology. Dr. Crooke is responsible for driving the development of antisense or ASO technology, an RNA-targeted technology responsible for the commercialization of three best- and first-in class medicines and more than 40 drugs in development. In 2020, Stan formed n-Lorem to use this powerful technology to develop experimental personalized ASO medicines for nano-rare patients (1 to 30 patients worldwide) for free, for life.


Hosted by: Dr. Stan Crooke.
Videographer: Jon Magnuson of Mighty One Productions.
Producers: Colin Delaney, Kira Dineen, Jon Magnuson, Andrew Serrano and Amy Williford

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