Medical Science 20

How to Think About “Risk” Part 1

December 6, 2023


Patients and caregivers frequently grapple with profoundly intricate and challenging decisions that carry significant risks.

“How to Think About Risk” is arguably the most crucial topic ever discussed on the Patient Empowerment Program. Navigating decisions with substantial risk can be challenging, intricate, and even intimidating. The ability to detach from the intense emotions surrounding these choices is critical for making the best and most logical decisions.

On This Episode We Discuss:

  • Why nano-rare patients and their families need to think effectively about risk
  • Risk vignettes: infectious diseases, automobile and smoking deaths
  • A rational way to think about risk
  • Being comfortable with a probabilistic reality
  • The 80/20 rule
  • Considering consequences
  • The process to assess risk
  • Getting serious about risk/benefit evaluations
  • Risk/benefit judgements

Watch on YouTube:

Download Script:

For more information on the covered topics or to follow along with this Intro to Medical Science episode, download the supporting transcript.



For definitions of terms, search our glossary.


The host of the show is Dr. Stanley Crooke, a scientist, a physician, an entrepreneur and the father of antisense technology. Dr. Crooke is responsible for driving the development of antisense or ASO technology, an RNA-targeted technology responsible for the commercialization of three best- and first-in class medicines and more than 40 drugs in development. In 2020, Stan formed n-Lorem to use this powerful technology to develop experimental personalized ASO medicines for nano-rare patients (1 to 30 patients worldwide) for free, for life.


Hosted by: Dr. Stan Crooke.
Videographer: Jon Magnuson of Mighty One Productions.
Producers: Colin Delaney, Kira Dineen, Jon Magnuson, Andrew Serrano and Amy Williford

More from n-Lorem:

See what else we are up to on Twitter, Instagram, Facebook, LinkedIn, YouTube and our website, If you enjoy this episode, please rate and review us, as it helps others find our podcast. Questions/inquiries can be sent to [email protected].

Listen to our next Intro to Medical Science episode:

How to Think About “Risk” Part 2

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We hope that you join us on this journey to discover, develop and provide individualized antisense medicines for free for life for nano-rare patients. The ultimate personalized medicine approach – for free, for life.

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Join us on our Corps of Discovery of the mind and heart. Help us bring hope and potential help to nano-rare patients today. For free, for life.

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