Medical Science 24

Why We Dose Intrathecally

July 10, 2024


Intrathecal administration is a method of delivering medication by injecting it into the cerebrospinal fluid

The affected organs of our patients determine the route of administration for an ASO, as certain routes can better target specific organs and offer the best potency. The central nervous system (CNS) is the most common target we encounter, and for this, we dose intrathecally. Let’s dive into how this is done and the particulars of why this approach is used.  

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On This Episode We Discuss:

  • The Human Body and Barriers
  • The Four Tubes – Enteral, Respiratory, Urinary, and the Central Nervous System (CNS) tube
  • How The Body Constructs Barriers 
  • What is Cerebrospinal Fluid (CSF) 
  • The Blood-Brain Barrier (BBB) 
  • The Types of Molecules That Are Admitted to and Excluded From the CNS 
  • Intrathecal Administration of Drugs 
  • Outwitting the Blood-Brain Barrier 

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The host of the show is Dr. Stanley Crooke, a scientist, a physician, an entrepreneur and the father of antisense technology. Dr. Crooke is responsible for driving the development of antisense or ASO technology, an RNA-targeted technology responsible for the commercialization of three best- and first-in class medicines and more than 40 drugs in development. In 2020, Stan formed n-Lorem to use this powerful technology to develop experimental personalized ASO medicines for nano-rare patients (1 to 30 patients worldwide) for free, for life.


Hosted by: Dr. Stan Crooke.
Videographer: Jon Magnuson of Mighty One Productions.
Producers: Colin Delaney, Kira Dineen, Jon Magnuson, Andrew Serrano and Amy Williford

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