Medical Science 34
What Are iPSCs—and Why Do They Matter?
May 28, 2025
Spotify
Amazon Music
Apple Podcasts
Google Podcasts
Induced pluripotent stem cells (iPSCs) are a groundbreaking, and mind-blowing, scientific advancement—one of many that help make it possible for n-Lorem to do what we do. In short, typical skin cells (such as fibroblasts) are taken from an individual and reprogrammed using specific factors to become iPSCs. These iPSCs are then redifferentiated into any desired cell type in the body, such as muscle or liver cells. You can do that? Yes, and we do! The most common cell type that we use at n-Lorem are neurons (nerve cells). These cells are not easily accessible in living humans without serious surgeries and that is why scientists instead use iPSCs to grow them.
In This Episode, We Explore:
1:23 – What are Induced Pluripotent Stem Cells?
5:45 – Chromatin – compressed DNA and proteins
9:13 – Differentiation and de-differentiation
10:26 – Transcription and transcription factors
12:35 – Why are iPSCs important?
15:20 – Making iPSC and re-differentiating them into the cells we study is time consuming and expensive
Watch on YouTube:
The host of the show is Dr. Stanley Crooke, a scientist, a physician, an entrepreneur and the father of antisense technology. Dr. Crooke is responsible for driving the development of antisense or ASO technology, an RNA-targeted technology responsible for the commercialization of three best- and first-in class medicines and more than 40 drugs in development. In 2020, Stan formed n-Lorem to use this powerful technology to develop experimental personalized ASO medicines for nano-rare patients (1 to 30 patients worldwide) for free, for life.
Credits
Hosted by: Dr. Stan Crooke.
Videographer: Jon Magnuson of Mighty One Productions.
Producers: Kira Dineen, Jon Magnuson, Andrew Serrano and Amy Williford
Listen to our next Intro to Medical Science episode
Antisense (How we do it at n-Lorem)
We cannot do
this alone
Together we are changing the world—
one patient at a time
We hope that you join us on this journey to discover, develop and provide individualized antisense medicines for free for life for nano-rare patients. The ultimate personalized medicine approach – for free, for life.
Follow us on social for updates on our latest efforts
