As the 2025 Nano-rare Patient Colloquium approaches, we welcome back Transmitter Features Editor Brady Huggett to guest-host this episode of the Patient Empowerment Program podcast. Brady sits down with n-Lorem founder and CEO, Dr. Stan Crooke, to reflect onto reflect on the strides made over the past year—insights that will help shape the discussions at this year’s Colloquium.

• 2:10 How n-Lorem decides to give a medicine specifically designed for one person to another individual
• 8:10 n-Lorem built systems to be able to treat more than one patient with a single drug
• 11:08 n-Lorem creates medicines for nano-rare genetically caused forms of ALS
• 15:14 New suggestions about the plasticity of the central nervous system and the future of medicine
• 19:40 Why science isn’t in a good place and will experience lasting repercussions
• 25:00 The Colloquium will focus on what we’ve learned at n-Lorem and what was once thought to be impossible is possible
• 27:34 An update on the quantity of INDs filed and patients treated with an n-Lorem ASO
• 28:80 The benefits of implementing whole genome sequencing (WGS) at birth
• 30:37 What surprises have emerged throughout the organizational journey of n-Lorem

Brady Huggett is the features editor at The Transmitter, and also hosts the podcast Synaptic. Previously, he served as business editor at Nature Biotechnology. Brady has a B.S. in biology from Wake Forest University in Winston-Salem, North Carolina, and an M.A. in journalism from the University of North Carolina at Chapel Hill.

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