The Interaction of Phosphorothioate Containing RNA Targeted Drugs with Proteins is a Critical Determinant of The Therapeutic Effects of These Agents
Crooke, S.T., Seth., P.P., Vickers, T.A., Liang, X.H.
Phosphorothioate modified oligonucleotide–protein interactions
Crooke, S.T., Vickers, T.A., Liang, X.H.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
Migawa, M.T., Shen, W, Wan, W.B., Vasquez, G., Oestergaard, M.E., Low, A., De Hoyos, C.L., Gupta, R., Murray, S., Tanowitz, M., Bell, M., Nichols, J.G., Gaus, H., Liang, X.H., Swayze, E.E., Crooke, S.T., Seth, P.P.
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Shen, W., De Hoyos, C.L., Migawa, M.T., Vickers, T.A., Sun, H., Low, A., Bell, T.A. 3rd., Rahdar, M., Mukhopadhyay, S., Hart, C.E., Bell, M., Riney, S., Murray, S.F., Greenlee, S., Crooke, R.M., Liang, X.H., Seth, P.P., Crooke, S.T.
Integrated Assessment of the Clinical Performance of GalNAc3-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience
Crooke, S.T., Baker B.F., Xia, S., Yu., R.Z., Viney, N.J., Wang, Y., Tsimikas, S., Geary, R.S. Download PDF
RNA-Targeted Therapeutics
Crooke, S.T., Witztum, J.L., Bennett, C.F., Baker, B.F.
The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans
Crooke, S.T., Baker, B.F., Pham, N.C., Hughes, S.G., Kwoh, T.J., Cai, D., Tsimikas, S., Geary, R.S., Bhanot, S. Download PDF
The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials
Crooke, S.T., Baker, B.F., Witztum, J.L., Kwoh, T.J., Pham, N.C., Salgado, N., McEvoy, B.W., Cheng, W., Hughes, S.G., Bhanot, S., Geary, R.S. Download PDF
Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers
Crooke, S.T., Baker, B.F., Kwoh, T.J., Cheng, W., Schilz, D.J., Xia, S., Salgado, N., Bui, H., Hart, C.E., Burel, S.A., Younis, H.S., Geary, R.S., Henry, S.P., Bhanot, S. Download PDF
