Ultra-precision medicine
Crooke, S.T.
Nonclinical Testing of Individualized Antisense Oligonucleotide Drug Products for Severely Debilitating or Life-Threatening Diseases
U.S. Department of Health and Human Services
Food and Drug Administration
Center for Drug Evaluation and Research (CDER)
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Antisense Technology: An Overview and Prospectus
Crooke, S.T., Baker, B.F., Crooke R.M., Liang, X.H.
Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs
Vasquez, G., Freestone, G.C., Wan, W.B., Low, A., De Hoyos, C.L., Yu, J., Prakash, T.P., Østergaard, M.E., Liang, X.H., Crooke, S.T., Swayze, E.E., Migawa, M.T., Seth, P.P.
IND Submissions for Individualized Antisense Oligonucleotide Drug Products: Administrative and Procedural Recommendations
U.S. Department of Health and Human Services
Food and Drug Administration
Center for Drug Evaluation and Research (CDER)
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Antisense Drug Discovery and Development Technology Considered in a Pharmacological Context
Crooke, S.T., Liang, X.H., Crooke R.M., Baker, B.F., Geary, R.S.
The Interaction of Phosphorothioate Containing RNA Targeted Drugs with Proteins is a Critical Determinant of The Therapeutic Effects of These Agents
Crooke, S.T., Seth., P.P., Vickers, T.A., Liang, X.H.
Phosphorothioate modified oligonucleotide–protein interactions
Crooke, S.T., Vickers, T.A., Liang, X.H.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins
Migawa, M.T., Shen, W, Wan, W.B., Vasquez, G., Oestergaard, M.E., Low, A., De Hoyos, C.L., Gupta, R., Murray, S., Tanowitz, M., Bell, M., Nichols, J.G., Gaus, H., Liang, X.H., Swayze, E.E., Crooke, S.T., Seth, P.P.
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
Shen, W., De Hoyos, C.L., Migawa, M.T., Vickers, T.A., Sun, H., Low, A., Bell, T.A. 3rd., Rahdar, M., Mukhopadhyay, S., Hart, C.E., Bell, M., Riney, S., Murray, S.F., Greenlee, S., Crooke, R.M., Liang, X.H., Seth, P.P., Crooke, S.T.
