Open Positions

Come join our team of talented and passionate individuals to help the nano-rare patient community.

n-Lorem Foundation

The mission of the foundation is to take advantage of the efficiency, versatility and specificity of antisense technology to provide charitably investigational antisense oligonucleotide (ASO) drugs to treat patients with nano-rare diseases (n1-30 patients). We plan a collaboration between the Foundation, the Undiagnosed Disease Network (UDN), investigators and institutions that comprise the UDN and Ionis Pharmaceuticals. Although each partner is fully independent, to maximize the efficiency with which efficacious therapies may be delivered to patients with rare diseases, there will be substantial interaction among the three partners.

Research Associate


Reporting to: Director of Research and Development

Location: El Cajon, CA

Job Overview

  • Perform tissue culture of common human cell lines as well as reprogrammed cells and ipsc derived cells.
  • Perform drug treatment assays including transfection and free uptake.
  • Maintain a well-organized, clean, and safe lab working environment.
  • Maintain inventory, ordering supplies, and ensuring laboratory equipment is performing within specifications.
  • Plan, execute and analyze experiments under supervision.
  • Summarize and report experimental data and relevant documents to supervisors.
  • May present data in group meetings.
  • Other responsibilities as assigned.


  • US work authorization.
  • >1 year experience establishing/performing molecular/cellular/biochemical assays.
  • Hold a B.A/B.S. degree in Biology or related field.
  • Have strong attention to detail.
  • Possess excellent written and verbal communication skills.
  • Demonstrate an ability to work as part of team and possess an excellent work ethic.
  • Have the ability to be successful in a fast-paced, intense work environment.

Preferred Qualifications

  • Experience troubleshooting molecular/cellular biology techniques and/or biochemical assays
  • Experience with high throughput gene transfection, high throughput RNA isolation, and high throughput real-time PCR.
  • Experience with liquid handling automated workstations.
  • Industry experience with ASO/RNAi technology.
  • Knowledge of biostatistics.
  • Work experience with CROs.

To apply for this position please click the link below.

Senior Research Associate


Reporting to: Director of Research and Development
Location: El Cajon, CA

Job Overview

The successful candidate will work within a fast-paced, interactive, and innovative research team to answer key mutation-dependent questions using outstanding molecular/cellular/biochemical techniques to discover and validate novel antisense drugs for nano-rare diseases. Responsibilities will include assisting with strategic planning, design, execution, trouble-shooting, and analysis of in vitro experiments to evaluate potential clinical development compounds in addition to disease relevant biology in human cell culture systems. We are looking for a highly motivated individual with strong attention to detail, capable of multi-tasking and who would succeed in a fast-paced atmosphere.


  • US work authorization.
  • PhD degree in Biology, or a related field.
  • > 2 years of postdoctoral or professional experience in an academic or industry research setting, with a proven track record of accomplishments, including publications in top tier scientific journals.
  • Demonstrated experience with culturing human cell lines, fibroblasts, and ips-derived cells is required.
  • Demonstrated experience performing screening assays and analysis.
  • Essential laboratory skills including RNA and protein analysis such as qPCR, Western blot, and ELISA are required. Additional in vitro skill sets are highly desired including automation.
  • Translational biology experience developing biomarkers are a plus.
  • Have strong interpersonal skills including a proven track record of building and maintaining effective working relationships with teams and partners.
  • Have the ability to manage multiple assignments effectively in a quickly evolving environment.
  • Outstanding communication and team skills.
  • Self-starter who is highly motivated and not afraid to take risks

To apply for this position please click the link below.

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